Lewis county is in the Outer Bluegrass and Eastern Coal Field regions of Kentucky. The elevation in the county ranges from 485 to 1400 feet above sea level.
It was formed in 1807 from Mason county. Lewis county was a source of Beckham (1904) county. The county seat is Vanceburg.
In 2020 the county population was 13,080 in a land area of 482.84 square miles, an average of 27.1 people per square mile.
The equine population was 1,400 in the 2012 Kentucky Equine Survey.
Lewis county is in the Buffalo Trace Area Development District. It is in the Appalachian region according to the Appalachian Regional Commission.
Lewis county was named for Merriweather Lewis.
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