Henderson county is in the Western Coal Field region of Kentucky. The elevation in the county ranges from 331 to 588 feet above sea level.
It was formed in 1799 from Christian county. The county seat is Henderson. Henderson county was a source of Hopkins (1807), Union (1811), and Webster (1860) counties.
In 2020 the county population was 44,793 in a land area of 436.67 square miles, an average of 102.6 people per square mile.
The equine population was 1,300 in the 2012 Kentucky Equine Survey.
Henderson county is in the Evansville metro statistical area and the Green River Area Development District.
Henderson county was named to honor Richard Henderson, founder of the Transylvania Company.
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